Dr Dom Gorse
PhD (Computer Science), MBA, FAIDH
Director, Data Scientist
Data Science Collaborative Research Platform
+61 7 3346 2624
- Over 30 years of experience in applying machine learning algorithms, statistical analysis, and computational models to large-scale datasets, including techniques such as dimensionality reduction, variable selection, clustering, and neural networks.
- Expertise in designing and managing research infrastructure for bioinformatics and digital health, ensuring robust data handling, security, and compliance with privacy and ethical standards.
- Provides expert advice on data governance and best practices to ensure the secure handling, storage, and processing of sensitive data.
- Provides supervision, mentorship and trainings to HDR students for cheminformatics projects.
Book Chapter
Leroux, Hugo, Dallest, Kathy, Kang, Kristan, Gottliebsen, Sara, Gorse, Dominique, Guillen, Diego and Hansen, David (2024). Promoting the Secondary Use of Clinical Research Data in Australia. Studies in Health Technology and Informatics. IOS Press. doi: 10.3233/shti240918
Journal Articles
Eden, Rebekah, Chukwudi, Ignatius, Bain, Chris, Barbieri, Sebastiano, Callaway, Leonie, de Jersey, Susan, George, Yasmeen, Gorse, Alain-Dominique, Lawley, Michael, Marendy, Peter, McPhail, Steven M., Nguyen, Anthony, Samadbeik, Mahnaz and Sullivan, Clair (2025). A scoping review of the governance of federated learning in healthcare. npj Digital Medicine, 8 (1) 427, 427-1. doi: 10.1038/s41746-025-01836-3
Engstrom, Teyl, Lobo, Elton H., Watego, Kristie, Nelson, Carmel, Wang, Jinxiang, Wong, Howard, Kim, Sungkyung Linda, Oh, Soo In, Lawley, Michael, Gorse, Alain-Dominique, Ward, James and Sullivan, Clair (2024). Indigenous data governance approaches applied in research using routinely collected health data: a scoping review. npj Digital Medicine, 7 (1) 68, 1-9. doi: 10.1038/s41746-024-01070-3
Hesping, Eva, Chua, Ming Jang, Pflieger, Marc, Qian, Yunan, Dong, Lilong, Bachu, Prabhakar, Liu, Ligong, Kurz, Thomas, Fisher, Gillian M., Skinner-Adams, Tina S., Reid, Robert C., Fairlie, David P., Andrews, Katherine T. and Gorse, Alain-Dominique J.P. (2022). QSAR classification models for prediction of hydroxamate histone deacetylase inhibitor activity against malaria parasites. ACS Infectious Diseases, 8 (1), 106-117. doi: 10.1021/acsinfecdis.1c00355
Delbaz, Ali, Chen, Mo, Jen, Freda E-C, Schulz, Benjamin L., Gorse, Alain-Dominique, Jennings, Michael P., St John, James A. and Ekberg, Jenny A K (2020). Neisseria meningitidis induces pathology-associated cellular and molecular changes in trigeminal Schwann cells. Infection and Immunity, 88 (4) e00955-19. doi: 10.1128/IAI.00955-19
Thang, Mike W. C., Chua, Xin-Yi, Price, Gareth, Gorse, Dominique and Field, Matt A. (2019). MetaDEGalaxy: Galaxy workflow for differential abundance analysis of 16s metagenomic data. F1000Research, 8 726, 1-17. doi: 10.12688/f1000research.18866.2
Pineda, Sandy S., Chaumeil, Pierre-Alain, Kunert, Anne, Kaas, Quentin, Thang, Mike W. C., Le, Lien, Nuhn, Michael, Herzig, Volker, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, Senff, Sebastian, Gorse, Dominique and King, Glenn F. (2017). ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins. Bioinformatics, 34 (6), 1074-1076. doi: 10.1093/bioinformatics/btx661
Schneider, Maria Victoria, Griffin, Philippa C., Tyagi, Sonika, Flannery, Madison, Dayalan, Saravanan, Gladman, Simon, Watson-Haigh, Nathan, Bayer, Philipp E., Charleston, Michael, Cooke, Ira, Cook, Rob, Edwards, Richard J., Edwards, David, Gorse, Dominique, McConville, Malcolm, Powell, David, Wilkins, Marc R. and Lonie, Andrew (2017). Establishing a distributed national research infrastructure providing bioinformatics support to life science researchers in Australia. Briefings in Bioinformatics, 20 (2), 384-389. doi: 10.1093/bib/bbx071
Vial, Marie-Laure, Zencak, Dusan, Grkovic, Tanja, Gorse, Alain-Dominique, Mackay-Sim, Alan, Mellick, George D., Wood, Stephen A. and Quinn, Ronald J. (2016). A grand challenge. 2. Phenotypic profiling of a natural product library on Parkinson's patient-derived cells. Journal of Natural Products, 79 (8), 1982-1989. doi: 10.1021/acs.jnatprod.6b00258
Gibb, Michelle, Chua, Xin-Yi, Gorse, Dominique and Queen, Douglas (2015). The Australian wound registry. Australian nursing & midwifery journal, 23 (3).
Straube, Jasmin, Gorse, Alain-Dominique, Huang, Bevan Emma and Le Cao, Kim-Anh (2015). A Linear Mixed Model Spline Framework for Analysing Time Course 'Omics' Data. PLoS One, 10 (8) e0134540, e0134540-e0134540. doi: 10.1371/journal.pone.0134540
Amani, Parisa, Sneyd, Todd, Preston, Sarah, Young, Neil D., Mason, Lyndel, Bailey, Ulla-Maja, Baell, Jonathan, Camp, David, Gasser, Robin B, Gorse, Alain-Dominique, Taylor, Paul and Hofmann, Andreas (2015). A practical Java tool for small-molecule compound appraisal. Journal of Cheminformatics, 7 (1) 28, 28.1-28.4. doi: 10.1186/s13321-015-0079-1
Sarnpitak, Pakornwit, Mujumdar, Prashant, Taylor, Paul, Cross, Megan, Coster, Mark J., Gorse, Alain-Dominique, Krasavin, Mikhail and Hofmann, Andreas (2015). Panel docking of small-molecule libraries - prospects to improve efficiency of lead compound discovery. Biotechnology Advances, 33 (6), 941-947. doi: 10.1016/j.biotechadv.2015.05.006
Pascolutti, Mauro, Campitelli, Marc, Nguyen, Bao, Pham, Ngoc, Gorse, Alain-Dominique and Quinn, Ronald J. (2015). Capturing nature's diversity. PLoS One, 10 (4) e0120942, 1-12. doi: 10.1371/journal.pone.0120942
Islam, Mohammad Tawhidul, Mohamedali, Abidali, Garg, Gagan, Khan, Javed Mohammed, Gorse, Alain-Dominique, Parsons, Jeremy, Marshall, Peter, Ranganathan, Shoba and Baker, Mark S. (2013). Unlocking the puzzling biology of the Black Périgord truffle Tuber melanosporum. Journal of Proteome Research, 12 (12), 5349-5356. doi: 10.1021/pr400650c
Volker, Herzig, Wood, David, Newell, Felicity, Chaumeil, Pierre-Alain, Kaas, Quentin, Binford, Greta J., Nicholson, Graham M., Gorse, Dominique and King, Glenn F. (2011). ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures. Nucleic Acids Research, 39 (Supp. 1), D653-D657. doi: 10.1093/nar/gkq1058
Muir, Ben W., Barden, Michael C., Collett, Simon P., Gorse, Alain-Dominique, Monteiro, Raisa, Yang, Liqun, McDougall, Nicole A., Gould, Sharon and Maeji, N. Joe (2007). High-throughput optimization of surfaces for antibody immobilization using metal complexes. Analytical Biochemistry, 363 (1), 97-107. doi: 10.1016/j.ab.2007.01.015
Gorse A.-D. (2006). Diversity in medicinal chemistry space. Current Topics in Medicinal Chemistry, 6 (1), 3-18. doi: 10.2174/156802606775193310
Ashton M., Barnard J., Casset F., Charlton M., Downs G., Gorse D., Holliday J., Lahana R. and Willett P. (2002). Identification of diverse database subsets using property-based and fragment-based molecular descriptions. Quantitative Structure-Activity Relationships, 21 (6), 598-604. doi: 10.1002/qsar.200290002
Gorse D. and Lahana R. (2000). Functional diversity of compound libraries. Current Opinion in Chemical Biology, 4 (3), 287-294. doi: 10.1016/S1367-5931(00)00091-0
Gorse D., Rees A., Kaczorek M. and Lahana R. (1999). Molecular diversity and its analysis. Drug Discovery Today, 4 (6), 257-264. doi: 10.1016/S1359-6446(99)01334-3
Gorse, AD and Gready, JE (1997). Molecular dynamics simulations of the docking of substituted N5-deazapterins to dihydrofolate reductase. Protein Engineering, 10 (1), 23-30. doi: 10.1093/protein/10.1.23
Lapouge, C, Cavagnat, D, Gorse, D and Pesquer, M (1995). Ring Puckering and Ch Stretching Spectra .1. Theoretical-Study of Gaseous Monohydrogenated Cyclopentenes 3-H(1) and 4-H(1). Journal of Physical Chemistry, 99 (10), 2996-3004. doi: 10.1021/j100010a007
Gorse, AD and Pesquer, M (1995). Intramolecular Charge-Transfer Excited-State Relaxation Processes in Parasubstituted N,n-Dimethylaniline - a Theoretical-Study Including Solvent Effects. Journal of Physical Chemistry, 99 (12), 4039-4049. doi: 10.1021/j100012a026
Fadouach, M, Kadiri, A, Cazeaudubroca, C, Nouch, G, Pesquer, M and Gorse, D (1994). Theoretical Stimulation of Rotation by Hydrogen-Bond of 2,2-Biquonine in the Ground-State. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 50 (12), 2117-2124. doi: 10.1016/0584-8539(94)80106-1
Gorse, AD and Pesquer, M (1994). The Use of Fragas Potential with Am1 Atomic Point Charges in the Evaluation of Spectral Shifts - Application to Tict Molecules. Journal of Computational Chemistry, 15 (10), 1139-1150. doi: 10.1002/jcc.540151010
Cazeaudubroca, C, Nouchi, G, Brahim, MB, Pesquer, M, Gorse, D and Cazeau, P (1994). Dual Fluorescence of 4-N,n-Dimethylaminopyridine - Role of Hydrogen-Bonded Complex in the Ground-State. Journal of Photochemistry and Photobiology A-Chemistry, 80 (1-3), 125-133. doi: 10.1016/1010-6030(93)01033-X
Gorse, Alain-Dominique and Pesquer, Michel (1993). A theoretical study of aniline and some derivatives in their ground states. Journal of Molecular Structure: THEOCHEM, 281 (1), 21-32. doi: 10.1016/0166-1280(93)80024-T
Gorse, AD and Pesquer, M (1993). A Theoretical-Study of Aniline and Some Derivatives in Their Ground-States. Theochem-Journal of Molecular Structure, 100 (1), 21-32.
Gorse, D, Cavagnat, D, Pesquer, M and Lapouge, C (1993). Theoretical and Spectroscopic Study of Asymmetric Methyl Rotor Dynamics in Gaseous Partially Deuterated Nitromethanes. Journal of Physical Chemistry, 97 (17), 4262-4269. doi: 10.1021/j100119a005
Conference Papers
Leonard, Conrad, Wood, Scott, Holmes, Oliver, Waddell, Nic, Gorse, Dominique, Hansen, David P. and Pearson, John V. (2019). Running genomic analyses in the cloud. Annual Australian national conference for Health Informatics HIC 2019, Melbourne, VIC Australia, 12 – 14 August 2019. IOS Press. doi: 10.3233/SHTI190787
Bradford, DanaKai, Pearson, John, Gorse, Dom, Metke, Alejandro, Leroux, Hugo, Dallest, Kathy, Bunker, David and Hansen, David (2019). Understanding the barriers to genomic healthcare in Queensland through an information management lens. Health Informatics Conference 2019, Melbourne, VIC Australia, 12-14 August 2019. Amsterdam, Netherlands: IOS Press. doi: 10.3233/SHTI190770
Cuddihy, Thom, Forde, Brian, Rhodes, Nicholas, Paterson, David, Gorse, Dominique, Beatson, Scott and Harris, Patrick (2019). SRA down under: cache and analysis platform for infectious disease. Australian national conference for Health Informatics (HIC 2019), Melbourne, Australia, 12-14 August 2019. Amsterdam, Netherlands: IOS Press. doi: 10.3233/SHTI190776