MRFF 2025 Cardiovascular Health

Key Dates for MRFF 2025 Cardiovascular Health

Proposals open in Sapphire: 12 February 2025
UQ R&I NOI Close: 16 July 2025
Minimum data requirements in Sapphire: 5pm ACT time 16 July 2025
Applications due to UQ R&I: 23 July 2025
Applications close: 5pm ACT time 13 August 2025

Overview

Consistent with the MRFF Act, the objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that:

Stream 1 (Priority Area 1.2; Targeted Call for Research): reduce the number of Australians experiencing cardiovascular disease and stroke by developing and implementing early, more effective preventive health interventions, by co-designing and developing strategies with Aboriginal and/or Torres Strait Islander people to embed best-practice, culturally secure cardiovascular disease and stroke prevention for Aboriginal and/or Torres Strait Islander people into care.

Stream 2 (Priority Area 2.2; Targeted Call for Research): conduct Phase 1 and Phase 2 clinical trials to demonstrate safety and potential efficacy of novel devices and therapeutic approaches for cardiovascular disease and stroke.

Steam 3 (Priority Area 3.2; Targeted Call for Research): conduct a large-scale multiomics project focused on improving understanding of recovery trajectories and phenotypes, underpinning recovery and survivorship in cardiovascular disease and stroke.

Stream 4 (Priority Area 1.2; Targeted Call for Research): reduce the number of Australians experiencing cardiovascular disease and stroke by developing and implementing early, more effective preventive health interventions.

Topic A: developing and implementing novel therapeutics/technologies for the prevention of cardiac disease caused by chronic diseases
Topic B: developing and implementing novel discoveries and markers to improve risk prediction
Topic C: developing and implementing novel approaches to tailor preventive care, support adherence and reduce inequalities

This grant opportunity is intended to support projects that progress research that addresses a specific health need.

For Stream 2, applications that propose to conduct a phase I trial, a phase II trial or a combined phase I/II trial are acceptable.

A person must not be named as a Chief Investigator (CI) on more than one application submitted to this grant opportunity.

Available funding

Stream 1: There is no minimum grant amount and the maximum amount available for a single grant is $2.0 million.
Stream 2: There is no minimum grant amount and the maximum amount available for a single grant is $3.0 million.
Stream 3: The minimum amount available for a single grant is $3.0 million and the maximum amount available for a single grant is $5.0 million.
Stream 4: There is no minimum grant amount and the maximum amount available for a single grant is $3.0 million.

How to Apply

Internal notice of intent process

All researchers intending to submit an MRFF application are required to submit a mandatory internal Notice of Intent. NOIs will be collated centrally and distributed to Faculties and Institutes in order to provide maximum support to the UQ research community.

Step 1. Sapphire updates and scheme reading

Register for Sapphire and update your full profile 'My Profile and CV'. The Grant Opportunity will be run through the new National Health and Medical Research Council (NHMRC) grants management system, Sapphire, which replaces RGMS. If any team members are new to Sapphire and need a login/password, start early. The NHMRC require at least three working days to create new Sapphire accounts.
Familiarise yourself with the key MRFF, NHMRC and The University of Queensland (UQ) documentation.

Step 2. Completing the application

Log into Sapphire and complete the application

Step 3. UQ R&I internal review and feedback

Ahead of internal review, ensure all online components are complete and valid in Sapphire and CIA has initiated the Certification process. Application errors will be signalled and can be corrected during the Certification stage.
To initiate internal review, email your completed Funding Application Certification to UQ R&I at mrffgrants@research.uq.edu.au.
Internal review by UQ R&I/feedback provided (compliance/eligibility/grantsmanship).

Step 4. Final submission

Final submission by UQ R&I to NHMRC.

Letters of Support

Signing for all letters of support from UQ is co-ordinated through the Research Office. All Letters of support for MRFF applications, including those led by other institutions, must be accompanied by a completed Funding Application Certification (see below) and authorisations of any enumerated contributions or additional UQ staff beyond the lead CI listed in the letter. We strongly recommend working with your local school/institute research professionals to complete this process.

To provide time for review and signature, we ask that UQ researchers submit draft letters to mrffgrants@research.uq.edu.au no later than two weeks before the external closing date.

Partner Letters

We would encourage applicants to provide drafts of partner letters of support for review by the Research office before organising their final signature to ensure eligibility and compliance. A template Letter of Support is provided below.

Non-UQ Lead Applications

The administering organisation should provide you with a draft letter of support. UQ information from the CEO letter below may assist you in completing the letter.
Complete a generic Funding Application Certification, and get it countersigned by your Head of School/Institute.
Submit both to mrffgrants@research.uq.edu.au, along with evidence for any additional co-contributions.

Readership and researcher support

Before applying, we recommend you:

Contact your faculty or institute research manager for advice on peer readership programs.
Join the UQ R&I Mailer to stay up to date with round developments.
Access the UQ R&I Grants Library, a helpful resource of past successful proposals.
If offered, attend UQ R&I information sessions and access PowerPoint presentations from presentations and slides.

Key documents

Before applying, please review the full suite of documents available from GrantConnect, the Australian Government grants information system and: